![]() Many associations have been identified with AMN and include: This theory of microthrombosis has also been observed in several cases of COVID-19 vaccination and infection. Another theory has been postulated regarding systemic inflammation in autoimmune diseases causing microthrombosis due to small-vessel occlusion, thus leading to ischemic retinopathy. ![]() The number of unilateral versus bilateral cases were similar though there was a slightly increased percentage of bilateral AMN (55 of 101 patients, 54.4%) as compared to unilateral AMN (45 of 101 patients, 44.5%).Īlthough exact mechanisms causing AMN have yet to be elucidated, there is evidence to suggest that vascular compromise of the deep retinal capillary plexus of the retina leads to the vision loss seen in patients with this disease. Most cases in this study were reported in young, white females in their third decade of life. Ī review article published in 2016 identified the largest series of 156 eyes of 101 patients with AMN. In the majority of patients, the fovea is spared however, prior studies have found patients with foveal involvement, including foveal hemorrhage, foveal granularity, and abnormal foveal reflex. Scotomas generally persist indefinitely, though some resolve partially over months. Patients with AMN report a sudden onset of one or more paracentral scotomas, decreased vision, and/or blurry vision. AMN is defined by the presence of intra-retinal, reddish-brown, wedge-shaped lesions around the fovea. Ganglion cell complex Inner plexiform layer Optical coherence tomography Primary open-angle glaucoma.Acute Macular Neuroretinopathy (AMN), first reported in 1975 (by Bos and Deutman), is a rare disease, commonly affecting young women, that causes transient or permanent vision loss. Loss of this layer is highly correlated with overall loss of visual field sensitivity. GCL + IPL layer thickness is a highly specific and sensitive parameter in differentiating glaucomatous from healthy eyes showing progressive damage as glaucoma worsens. Each micrometer decrease in the average GCL + IPL thickness was associated with a 0.54-dB loss in MD. Both thickness values showed significant correlations with MD. The areas under the receiver operating characteristic curve for average and minimum GCL + IPL thickness values were 0.93 and 0.94, respectively, sensitivity 91.5 and 88.3%, and specificity 98.9 and 100%, respectively. There were statistically significant differences in the average, minimum, and all 6 sectoral GCL + IPL values among the groups. The average GCL + IPL thickness of 154 eyes of 93 patients in glaucoma stages 1, 2, 3, and 94 eyes of 47 persons in the control group were 76.79 ± 8.05, 65.90 ± 7.92, 57.38 ± 10.00, and 86.01 ± 3.68 μm, respectively. The average, minimum, and all 6 sectoral (superotemporal, superior, superonasal, inferonasal, inferior, and inferotemporal) GCL + IPL thicknesses were measured and compared between groups. Glaucomatous damage was classified according to the Hodapp-Parrish-Anderson scale: glaucoma stage 1 (early), glaucoma stage 2 (moderate), and glaucoma stage 3 (severe). This prospective, cross- sectional study was conducted in a group of patients with confirmed POAG who were compared to an age- and gender-matched control group. To compare ganglion cell (GCL) and inner plexiform layer (IPL) thickness in patients at different stages of primary open-angle glaucoma (POAG), determine their sensitivity and specificity values, and correlate thickness values with mean deviations (MD).
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